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Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: Moreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-AktXKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signalingpathway in the skeletal muscle.

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

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Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: The aim of this research was to explore the effects and signaling pathway of ultraviolet-B (UVB) irradiationThe EGFR/PI3K/AKT signaling pathway was required for the induction of HIF-1α and TfR expression inducedPI3K inhibitors, LY294002 and wortmannin, inhibited HIF-1?We conclude that UVB induces TfR and HIF-1αexpressions via EGFR/PI3K/AKT/DEC1 signaling pathway.
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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: Gliomas are the most common central nervous system tumours; they are highly aggressive and have a poor prognosis. RGS16 belongs to the regulator of G-protein signalling (RGS) protein family, which plays an important role in promoting various cancers, such as breast cancer, pancreatic cancer, and colorectal cancer. Moreover, previous studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressor to regulate the progression of various tumours by inhibiting the expression of its target genes. However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7c-5p are still unknown. Here, we confirmed that RGS16 is upregulated in glioma tissues and that high expression of RGS16 is associated with poor survival. Ectopic deletion of RGS16 significantly suppressed glioma cell proliferation and migration both in vitro and in vivo. Moreover, RGS16 was validated as a direct target gene of miR let-7c-5p. The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking down miR let-7c-5p had the opposite effect. Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may serve as a potential prognostic biomarker and therapeutic target in glioma.

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 341-346 doi: 10.1007/s11684-009-0067-9

Abstract: Phosphatidylinositol 3-kinase (PI3K) is a crucial cell survival pathway implicated in tumorigenesis becausestudy was to investigate the regulation of proliferation and apoptosis by LY294002, an inhibitor of PI3KCell viability was measured by 3-(4,5)-dimethylthiazol(-2-y1)-3,5-di-phenyltetrazoliumbromide (MTT) assayThese results suggested that the PI3K/Akt signal pathway might be involved in the regulation of cellMoreover, the regulation of c-FLIP expression through PI3K/Akt signal pathway in cervical cancer cells

Keywords： human cervical cancer cells     apoptosis     phosphatidylinositol 3-kinase (PI3K)/Akt     FLICE-like inhibitory    

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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: GDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylationAKT and TGFBR2 inhibition resulted in the reversal of the GDF15-induced expression of UGT1A, indicatingthat TGFBR2-AKT pathway-dependent metabolic pathways were involved in the resistance of ESCC cells to

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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A 3D porous WP2 nanosheets@carbon cloth flexible electrode for efficient electrocatalytic hydrogen evolution

Mingyu Pi, Xiaodeng Wang, Dingke Zhang, Shuxia Wang, Shijian Chen

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 425-432 doi: 10.1007/s11705-018-1726-7

Abstract: /sub> nanosheet arrays on carbon fiber cloth (WP2 NSs/CC) were synthesized and used as a 3DBecause of its 3D porous nanoarray structure, the WP2 NSs/CC exhibits a remarkable catalyticevolution and provides a way to design and fabricate efficient hydrogen evolution electrodes through 3D

Keywords： WP2     nanosheet arrays     hydrogen evolution electrocatalyst     flexible electrode    

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Review of 4Pi Fluorescence Nanoscopy Review

Xiang Hao, Yiming Li, Shuang Fu, Yanghui Li, Yingke Xu, Cuifang Kuang, Xu Liu

Engineering 2022, Volume 11, Issue 4,   Pages 146-153 doi: 10.1016/j.eng.2020.07.028

Abstract: scientific advances have defied the diffraction limit in microscopy and enabled three-dimensional (3DAn important milestone in this pursuit is the coherent utilization of two opposing objectives (4Pi geometryHerein, we review the recent progress in 4Pi nanoscopy, which provides a 3D, non-invasive, diffraction-unlimitedThis review includes both the targeted and stochastic switching modalities of 4Pi nanoscopy.The schematics, principles, applications, and future potential of 4Pi nanoscopy are discussed in detail

Keywords： Fluorescence nanoscopy     Super-resolution imaging     4Pi nanoscopy     IsoSTED     4Pi-SMLM    

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Fatigue crack growth simulations of 3-D linear elastic cracks under thermal load by XFEM

K. YADAV

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 4,   Pages 359-382 doi: 10.1007/s11709-015-0304-z

Abstract: This paper deals with the fatigue crack growth simulations of three-dimensional linear elastic cracks by XFEM under cyclic thermal load. Both temperature and displacement approximations are extrinsically enriched by Heaviside and crack front enrichment functions. Crack growth is modelled by successive linear extensions, and the end points of these linear extensions are joined by cubic spline segments to obtain a modified crack front. Different crack geometries such as planer, non-planer and arbitrary spline shape cracks are simulated under thermal shock, adiabatic and isothermal loads to reveal the sturdiness and versatility of the XFEM approach.

Keywords： 3-D cracks     fatigue life     Paris law     thermal load     XFEM    

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Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1637-9

Abstract:

● Converting xylose to caproate under a low temperature of 20 °C by MCF was verified.

Keywords： Xylose fermentation     Caproate     Low temperature     Bifidobacterium     FAB pathway     RBO pathway    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract: Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- orANG II-induced downregulation of GSK-3β.The downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: Mechanistically, FRMD6 interacts and colocalizes with mTOR and S6K, which are the key molecules of themTOR signaling pathway.pS6K and downstream pS6 in lung cancer cells.Furthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signaling pathway

Keywords： FRMD6     lung cancer     mTOR pathway    

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Enhanced triallyl isocyanurate (TAIC) degradation through application of an O

Yapeng Song, Hui Gong, Jianbing Wang, Fengmin Chang, Kaijun Wang

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 4, doi: 10.1007/s11783-020-1243-z

Abstract: Abstract • UV/O3 process had higher TAIC mineralization rate than O3 process. • Four possible degradationTriallyl isocyanurate (TAIC, C12H15N3O3) has featured in wastewater treatment as a refractory organicapplication of an independent O3 process.rate that was much higher than that of the independent O3 process (9%) in 30 min.and O3/UV processes. pH impacted both the direct and indirect oxidation processes.

Keywords： Triallyl isocyanurate     O3/UV     Advanced oxidation processes (AOP)     Degradation pathway    

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Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 157-162 doi: 10.1007/s11684-011-0128-8

Abstract: At present, clinical pathway has become one of the most important health care reform measures in manyIn this study, the authors introduced basic concepts and explored the application of the clinical pathwaySuch concepts provide examples and experiences, on which the application of clinical pathway in Chinese

Keywords： evidence-based medicine     clinical pathway     methodology     concept     technical difficulty    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 403-409 doi: 10.1007/s11684-017-0522-y

Abstract:

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation

Keywords： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle    

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Control of peak pressures of an HCCI engine under varying swirl and operating parameters

AMBA PRASAD RAO,K. MADHU MURTHY

Frontiers in Energy 2016, Volume 10, Issue 3,   Pages 337-346 doi: 10.1007/s11708-016-0401-2

Abstract: For computational analysis, the ECFM-3Z model of STAR –CD is considered because it is suitable for analyzingAs an HCCI engine is a hybrid version of SI and CI engines, the ECFM-3Z model with necessary modificationsThe ECFM-3Z model for HCCI mode of combustion is validated with the existing literature to make sure

Keywords： HCCI engine     ECFM-3Z     Swirl ratio     peak pressures     engine speed     piston bowl geometry    

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Title Author Date Type Operation

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Journal Article

A 3D porous WP2 nanosheets@carbon cloth flexible electrode for efficient electrocatalytic hydrogen evolution

Mingyu Pi, Xiaodeng Wang, Dingke Zhang, Shuxia Wang, Shijian Chen

Journal Article

Review of 4Pi Fluorescence Nanoscopy

Xiang Hao, Yiming Li, Shuang Fu, Yanghui Li, Yingke Xu, Cuifang Kuang, Xu Liu

Journal Article

Fatigue crack growth simulations of 3-D linear elastic cracks under thermal load by XFEM

K. YADAV

Journal Article

Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

Enhanced triallyl isocyanurate (TAIC) degradation through application of an O

Yapeng Song, Hui Gong, Jianbing Wang, Fengmin Chang, Kaijun Wang

Journal Article

Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

Journal Article

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Journal Article

Control of peak pressures of an HCCI engine under varying swirl and operating parameters

AMBA PRASAD RAO,K. MADHU MURTHY

Journal Article